In my previous post, I wrote about Androgen Insensitivity Syndrome and a similar mutation connected with gender dysphoria. It was my position that such findings undermine the idea of XY chromosomes as an irrefutable indicator of maleness.
Through some random reading online about gender identity, I came across a new (or new to me) article that I feel offers even further weight to my position. A girl in Zurich was found to have XY chromosomes, and should by all right be a baby boy. But instead she is fully female, with a normal vagina, cervix and set of ovaries. The child in this has a mutation to the CBX2 gene which appears to completely shut down the genes responsible for male sexual development. This is a very different phenomenon than Androgen Insensitivity Syndrome, in which the sex organs are more ambiguous, and undeveloped testes are found in place of ovaries.
This discovery further demonstrates that while it may be typical for males to show an XY chromosome, this is far from being a given. Nature doesn't work in such cut & dry binaries.
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